Hydrochloric Acid → HCID 67112246, compound

HRID 2088885Notes

Reaction equation

HRID 2088885 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]([CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)[N:6]([CH2:8][CH2:9][O:10]C2CCCCO2)[CH:7]=1)[CH3:2].[Cl:30]CCl.[ClH:33]>CO>[ClH:30].[ClH:33].[CH2:1]([C:3]1[N:4]=[C:5]([CH:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)[N:6]([CH2:8][CH2:9][OH:10])[CH:7]=1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 67954721tert-butyl 4-(4-ethyl-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Product 1

HCID 67112246HCID 67112246, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Combine tert-butyl 4-(4-ethyl-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (4.70 g, 11.53 mmol), dichloromethane (100 mL), and methanol (50 mL). Add hydrogen chloride (20 mL) (4 M in dioxane) slowly. Stir overnight under nitrogen. Concentrate in vacuo to give the title compound (3.40 g, 100%). MS (ES) m/z=224 [M]+.

Workup

  1. concentrationConcentrate in vacuo

Sources & evidence

ORD record
ord-3b812242ebf2463d8fded53012c068d2
Source dataset
uspto-grants-2013_05
Patent number
US08436002B2

Reaction notes

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