HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-4-(4-(4-Ethyl-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 52913954 | HCID 52913954 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-4-(4-(4-Ethyl-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride | HCID 67112328 | 100% |
Reaction Steps
Add 4 M hydrochloric acid in dioxane (28.57 μL, 1.0 eq) to a solution of (R)-4-(4-(4-ethyl-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one (50.00 mg, 0.11 mmol) in dichloromethane (1 mL) at room temperature and stir for 15 minutes. Concentrate in vacuo to give the title compound (54.00 mg, 100%). MS (ES) m/z=438 [M]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436002B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-b23d517bd05842aea166a833f24f1935 |
| Source note | uspto-grants-2013_05 |