HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2088907Generated: October 31, 2026
Ammonia → 4-chloro-5-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one
https://huagongshe.com/reaction/2088907
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 86666567 | HCID 86666567 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-chloro-5-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one | HCID 86666566 | — |
Reaction Steps
Azeoptropically dry a solution as prepared in (b) containing methyl 3-(4,6-dichloropyrimidin-5-yl)butanoate (500 g, 2 mol) and add to a solution of ammonia gas (408 g) in isopropanol (6 L). Heat the mixture to 58-62° C. and stir for 40-45 h. Cool the mixture to 20-25° C. and concentrate until the pH of the mixture is ≦9. Add water (3.75
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08436002B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-430d7ef6e6c5425fa885178783ca783e |
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| Source note | uspto-grants-2013_05 |
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