反应详情

温度

60 °C

Azeoptropically dry a solution as prepared in (b) containing methyl 3-(4,6-dichloropyrimidin-5-yl)butanoate (500 g, 2 mol) and add to a solution of ammonia gas (408 g) in isopropanol (6 L). Heat the mixture to 58-62° C. and stir for 40-45 h. Cool the mixture to 20-25° C. and concentrate until the pH of the mixture is ≦9. Add water (3.75

1. customAzeoptropically dry a solution
2. customas prepared in (b)
3. temperatureCool the mixture to 20-25° C.
4. concentrationconcentrate until the pH of the mixture