反应详情

温度

120 °C

Combine methyl 3-(4,6-dichloropyrimidin-5-yl)-4,4,4-trifluorobutanoate (501.0 g, 1.57 mol) and 2 M ammonia in isopropyl alcohol (1.57 L, 2.0 eq) in a pressure reactor. Heat at 120° C. for seven hours. Cool the mixture to room temperature, then concentrate in vacuo. Dilute with hexanes (1 L). Filter to give crude product. Triturate this solid with 10% isopropyl alcohol in water (600 mL) and water (1.3 L). Filter and dry at 70° C. to give 4-chloro-5-(trifluoromethyl)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one (328.9 g, 83%) as a racemate. MS (ES) m/z=252 [M]+.

1. temperatureCool the mixture to room temperature
2. concentrationconcentrate in vacuo
3. additionDilute with hexanes (1 L)
4. filtrationFilter
5. customto give crude product
6. customTriturate this solid with 10% isopropyl alcohol in water (600 mL) and water (1.3 L)
7. filtrationFilter
8. customdry at 70° C.