Hydrochloric Acid → HCID 67112089, compound

HRID 2088927Notes

Reaction equation

HRID 2088927 reaction equation
O1CCCCC1[O:7][CH2:8][CH2:9][N:10]1[CH:14]=[C:13]([CH2:15][C:16]([F:19])([F:18])[F:17])[N:12]=[C:11]1[CH:20]1[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]1.[Cl:33]CCl.[ClH:36]>CO>[ClH:33].[ClH:36].[NH:23]1[CH2:24][CH2:25][CH:20]([C:11]2[N:10]([CH2:9][CH2:8][OH:7])[CH:14]=[C:13]([CH2:15][C:16]([F:18])([F:17])[F:19])[N:12]=2)[CH2:21][CH2:22]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 67112007HCID 67112007, compound

Product 1

HCID 67112089HCID 67112089, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Combine tert-butyl 4-(1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-4-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (3.12 g, 6.76 mmol), dichloromethane (88 mL), and methanol (35 mL). Add hydrogen chloride (17.3 mL, 10.2 eq) (4 M in dioxane) slowly. Stir overnight under nitrogen. Concentrate in vacuo to give 2-(2-(piperidin-4-yl)-4-(2,2,2-trifluoroethyl)-1H-imidazol-1-yl)ethanol dihydrochloride (2.37 g, 100%). MS (ES) m/z=278 [M]+.

Workup

  1. concentrationConcentrate in vacuo

Sources & evidence

ORD record
ord-94351756dd6d44b58e546a19c7f49668
Source dataset
uspto-grants-2013_05
Patent number
US08436002B2

Reaction notes

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