Ethyl Acetate → 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Participants

Reaction Steps

A mixture of Example 49a (6.2 g, 15.0 mmol) and OXONE® (92 g, 150 mmol) in ethyl acetate (350 ml) was stirred at 77° C. for 2 days. The reaction mixture was filtered and the solids were washed with dichloromethane. The organic phase was concentrated in vacuo to give the title compound (6.3 g, 14.2 mmol, 94% yield).

Provenance & Evidence