反应详情

A mixture of Example 49a (6.2 g, 15.0 mmol) and OXONE® (92 g, 150 mmol) in ethyl acetate (350 ml) was stirred at 77° C. for 2 days. The reaction mixture was filtered and the solids were washed with dichloromethane. The organic phase was concentrated in vacuo to give the title compound (6.3 g, 14.2 mmol, 94% yield).

1. filtrationThe reaction mixture was filtered
2. washthe solids were washed with dichloromethane
3. concentrationThe organic phase was concentrated in vacuo