Cyclohexylamine → HCID 66889103, compound

HRID 2088995Notes

Reaction equation

HRID 2088995 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7](S(C)(=O)=O)[N:6]=[C:5]([C:13]2[C:21]3[C:16](=[N:17][CH:18]=[CH:19][CH:20]=3)[N:15]([S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)(=[O:24])=[O:23])[CH:14]=2)[CH:4]=1.[CH:31]1([NH2:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>O1CCOCC1>[CH:31]1([NH:37][C:7]2[N:8]=[C:3]([O:2][CH3:1])[CH:4]=[C:5]([C:13]3[C:21]4[C:16](=[N:17][CH:18]=[CH:19][CH:20]=4)[N:15]([S:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)(=[O:24])=[O:23])[CH:14]=3)[N:6]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 668887123-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 66889103HCID 66889103, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of Example 49b (6.7 g, 15.1 mmol) and cyclohexanamine (6.90 ml, 60.3 mmol) in dioxane (165 ml) was heated at 100° C. overnight. The reaction mixture was concentrated in vacuo to afford the desired product (crude, 6.99 g, ˜15.1 mmol) which was used directly for the next step.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1b5c8bb921234c9e8c5a62e6953093fe
Source dataset
uspto-grants-2013_05
Patent number
US08435980B2

Reaction notes

Loading…