反应详情

A solution of Example 49b (6.7 g, 15.1 mmol) and cyclohexanamine (6.90 ml, 60.3 mmol) in dioxane (165 ml) was heated at 100° C. overnight. The reaction mixture was concentrated in vacuo to afford the desired product (crude, 6.99 g, ˜15.1 mmol) which was used directly for the next step.

1. concentrationThe reaction mixture was concentrated in vacuo