HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → HCID 66889103, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 66888712 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 66889103 | HCID 66889103 | 100% |
Reaction Steps
A solution of Example 49b (6.7 g, 15.1 mmol) and cyclohexanamine (6.90 ml, 60.3 mmol) in dioxane (165 ml) was heated at 100° C. overnight. The reaction mixture was concentrated in vacuo to afford the desired product (crude, 6.99 g, ˜15.1 mmol) which was used directly for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08435980B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-1b5c8bb921234c9e8c5a62e6953093fe |
| Source note | uspto-grants-2013_05 |