HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → 4-Bromo-N-cyclohexylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 4-Bromo-2-chloropyridine | HCID 3847770 | — |
| Product | 4-Bromo-N-cyclohexylpyridin-2-amine | HCID 53217452 | 12.8% |
Reaction Steps
A mixture of 4-bromo-2-chloropyridine (0.5 g, 2.6 mmol) and cyclohexylamine (0.26 g, 2.6 mmol) was heated in a CEM Microwave at 150 degrees for 15 minutes at 300 W. The resulting crude material was purified by flash chromatography (0% to 30% ethyl acetate/hexane) to give 85 mg of the title compound. MS m/z 256.8 (ESI: M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08435980B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-d1ff819c6cfc483ab6e65f354e53e916 |
| Source note | uspto-grants-2013_05 |