反应详情

温度

50 °C

A suspension of Example 149d (88.0 mg, 0.203 mmol) in ethanol (2 mL) was treated with a solution of potassium hydroxide (45.5 mg, 0.811 mmol) in water (0.5 mL). The reaction mixture was heated at 50° C. for 1.5 hours. After concentration, water was added to the residue and the mixture was sonicated. The solid was filtered, washed with water, and oven-dried to give 51.3 mg of the title compound.

1. concentrationAfter concentration, water
2. additionwas added to the residue
3. customthe mixture was sonicated
4. filtrationThe solid was filtered
5. washwashed with water
6. customoven-dried