HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2089018Generated: October 26, 2026
Potassium Hydroxide → 3-(2,6-Dichloro-4-pyridinyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridine
https://huagongshe.com/reaction/2089018
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-(2,6-dichloropyridin-4-yl)-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 87192554 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2,6-Dichloro-4-pyridinyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridine | HCID 87192183 | 85.9% |
Reaction Steps
A suspension of Example 149d (88.0 mg, 0.203 mmol) in ethanol (2 mL) was treated with a solution of potassium hydroxide (45.5 mg, 0.811 mmol) in water (0.5 mL). The reaction mixture was heated at 50° C. for 1.5 hours. After concentration, water was added to the residue and the mixture was sonicated. The solid was filtered, washed with water, and oven-dried to give 51.3 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08435980B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-e69bb49baf794e34b733545ae9b2740b |
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| Source note | uspto-grants-2013_05 |
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