HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzylamine → HCID 87191910, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | 3-(2,6-dichloropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 86649869 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 87191910 | HCID 87191910 | 39.9% |
Reaction Steps
A mixture of Example 7a (0.500 g, 1.24 mmol) and (4-methoxyphenyl)methanamine (1.018 g, 7.42 mmol) in acetonitrile (7 mL) was heated at 180° C. for 110 minutes The solvent was evaporated. The residue was treated with EtOAc and washed with 20% brine and 5% citric acid. The organic layer was concentrated and purified on a 100 g column using the ISCO Companion flash system eluting with CH2Cl2/EtOAc (98:2 to 95:5) to give 0.250 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08435980B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-dfa543197cdc4fbab9f7cb24bdd4dd30 |
| Source note | uspto-grants-2013_05 |