反应详情

A mixture of Example 7a (0.500 g, 1.24 mmol) and (4-methoxyphenyl)methanamine (1.018 g, 7.42 mmol) in acetonitrile (7 mL) was heated at 180° C. for 110 minutes The solvent was evaporated. The residue was treated with EtOAc and washed with 20% brine and 5% citric acid. The organic layer was concentrated and purified on a 100 g column using the ISCO Companion flash system eluting with CH2Cl2/EtOAc (98:2 to 95:5) to give 0.250 g of the title compound.

1. customwas evaporated
2. additionThe residue was treated with EtOAc
3. washwashed with 20% brine and 5% citric acid
4. concentrationThe organic layer was concentrated
5. custompurified on a 100 g column
6. washeluting with CH2Cl2/EtOAc (98:2 to 95:5)