反应详情

To a solution of Example 150b (0.262 g, 0.681 mmol) in DMF (6 mL) was added pyridine (0.11 mL, 1.36 mmol) and 2-chloroacetyl chloride (0.060 mL, 0.749 mmol). After 2 hours, the suspension was filtered. The filtrate was treated with water slowly. The precipitate formed was filtered, washed with water, and oven-dried to give 0.289 g of the title compound.

1. filtrationthe suspension was filtered
2. additionThe filtrate was treated with water slowly
3. customThe precipitate formed
4. filtrationwas filtered
5. washwashed with water
6. customoven-dried