反应详情

温度

120 °C

A mixture of trans-cyclohexane-1,4-diamine (2.085 g, 18.26 mmol) and 2,6-dichloro-4-iodopyridine (1.000 g, 3.65 mmol) was heated in a capped vial at 120° C. After 5 hours, the reaction mixture was cooled. The solids were stirred in EtOAc for 30 minutes, and the suspension was filtered. The filtrate was diluted with EtOAc and washed with 20% brine and NaHCO3. The organic layer was dried and concentrated to give 1.20 g of the title compound. The crude product was used in the next step without further purification.

1. temperaturethe reaction mixture was cooled
2. filtrationthe suspension was filtered
3. additionThe filtrate was diluted with EtOAc
4. washwashed with 20% brine and NaHCO3
5. customThe organic layer was dried
6. concentrationconcentrated