Sodium Hydroxide → HCID 178493708, compound

HRID 2089038Notes

Reaction equation

HRID 2089038 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:11][CH2:10]2)[CH:5]=[C:4]([C:23]2[C:31]3[C:26](=[N:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=3)[N:25](S(C3C=CC=CC=3)(=O)=O)[CH:24]=2)[CH:3]=1.[OH-].[Na+]>O1CCOCC1>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:21])[CH3:19])[CH2:11][CH2:10]2)[CH:5]=[C:4]([C:23]2[C:31]3[C:26](=[N:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=3)[NH:25][CH:24]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178493666HCID 178493666, compound

Product 1

HCID 178493708HCID 178493708, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

A solution of Example 213d (0.500 g, 0.817 mmol) in dioxane (3.0 mL) was treated with 20% NaOH. The reaction mixture was heated at 100° C. for an hour. The solvent was evaporated and the residue was treated with water, sonicated, filtered, washed with water again, and oven-dried to give 0.289 g (75%) of the title compound.

Workup

  1. customThe solvent was evaporated
  2. additionthe residue was treated with water
  3. customsonicated
  4. filtrationfiltered
  5. washwashed with water again
  6. customoven-dried

Sources & evidence

ORD record
ord-e6baf08c0a374905a0a7606b0007159f
Source dataset
uspto-grants-2013_05
Patent number
US08435980B2

Reaction notes

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