Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 178493666 | HCID 178493666 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178493708 | HCID 178493708 | 75% |
Reaction Steps
A solution of Example 213d (0.500 g, 0.817 mmol) in dioxane (3.0 mL) was treated with 20% NaOH. The reaction mixture was heated at 100° C. for an hour. The solvent was evaporated and the residue was treated with water, sonicated, filtered, washed with water again, and oven-dried to give 0.289 g (75%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08435980B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-e6baf08c0a374905a0a7606b0007159f |
|---|
| Source note | uspto-grants-2013_05 |
|---|
