反应详情

Aluminium chloride (3.7 g) is dissolved in nitromethane (12 ml) under nitrogen followed by N-(2-methyl-indan-2-yl)-benzamide (3.0 g) at 0° C. Acetyl chloride (0.85 ml) is added dropwise over 30 minutes. After 4 hours at room temperature the mixture is quenched with ice and concentrated HCl, extracted with DCM. The organic layers are washed with dilute HCl and brine. Evaporation of the solvent yielded the desired product. ES+ MS m/e 294 (MH+)

1. customAfter 4 hours at room temperature the mixture is quenched with ice and concentrated HCl
2. extractionextracted with DCM
3. washThe organic layers are washed with dilute HCl and brine
4. customEvaporation of the solvent