N-(5-Ethyl-2-methyl-indan-2-yl)-benzamide → N-(5-Ethyl-2-methyl-indan-2-yl)-benzamide

HRID 2089098Notes

Reaction equation

HRID 2089098 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][C:7]([NH:13][C:14](=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([CH3:12])[CH2:6]2)[CH3:2].[C:22]([C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[CH2:30][C:29]([NH:35][C:36](=[O:43])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)([CH3:34])[CH2:28]2)(=[O:24])[CH3:23]>>[C:22]([C:11]1[CH:10]=[C:9]2[C:5](=[CH:4][C:3]=1[CH2:1][CH3:2])[CH2:6][C:7]([NH:13][C:14](=[O:21])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)([CH3:12])[CH2:8]2)(=[O:24])[CH3:23].[CH2:22]([C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[CH2:30][C:29]([NH:35][C:36](=[O:43])[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)([CH3:34])[CH2:28]2)[CH3:23]

Participants

4

Reactant 2

HCID 22499186N-(5-Ethyl-2-methyl-indan-2-yl)-benzamideHCID 22499217N-(5-acetyl-2-methyl-indan-2-yl)-benzamide

Product 2

HCID 22499186N-(5-Ethyl-2-methyl-indan-2-yl)-benzamideHCID 22499225N-(5-Acetyl-6-ethyl-2-methyl-indan-2-yl)-benzamide

Procedure

N-(5-Acetyl-6-ethyl-2-methyl-indan-2-yl)-benzamide is prepared from N-(5-ethyl-2-methyl-indan-2-yl)-benzamide (2.6 g) following the procedure used to prepare N-(5-acetyl-2-methyl-indan-2-yl)-benzamide. The product is purified by chromatography (silica, hexane/ethyl acetate, 4:1) to give the title compound. ES+ MS m/e 322 (MH+)

Workup

  1. customThe product is purified by chromatography (silica, hexane/ethyl acetate, 4:1)

Sources & evidence

ORD record
ord-e737796fb3774b369686176398e34617
Source dataset
uspto-grants-2013_05
Patent number
US08436017B2

Reaction notes

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