AGN-PC-0ND25R → N-[1-(4-Benzo[1,3]dioxol-5-yl-cyclohexyl)-azetidin-3-yl]-2-(5-trifluoromethoxy-benzo[d]isoxazol-3-ylamino)-acetamide

HRID 2089145Notes

Reaction equation

HRID 2089145 reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:30])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([O:25][C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1.[O:31]1[C:35]2[CH:36]=[CH:37][C:38]([CH:40]3[CH2:45][CH2:44][C:43](=O)[CH2:42][CH2:41]3)=[CH:39][C:34]=2[O:33][CH2:32]1>>[O:31]1[C:35]2[CH:36]=[CH:37][C:38]([CH:40]3[CH2:45][CH2:44][CH:43]([N:8]4[CH2:9][CH:10]([NH:12][C:13](=[O:30])[CH2:14][NH:15][C:16]5[C:20]6[CH:21]=[C:22]([O:25][C:26]([F:28])([F:27])[F:29])[CH:23]=[CH:24][C:19]=6[O:18][N:17]=5)[CH2:11]4)[CH2:42][CH2:41]3)=[CH:39][C:34]=2[O:33][CH2:32]1

Participants

3

Reactant 2

HCID 10932904AGN-PC-0ND25RHCID 86660177N-azetidin-3-yl-2-(5-trifluoromethoxy-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt

Product 1

HCID 58548851N-[1-(4-Benzo[1,3]dioxol-5-yl-cyclohexyl)-azetidin-3-yl]-2-(5-trifluoromethoxy-benzo[d]isoxazol-3-ylamino)-acetamide

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethoxy-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt (as prepared in Example 1, Step D) and 4-benzo[1,3]dioxol-5-yl-cyclohexanone using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-3e68efb7a0ff479bb3335c0e65f83d07
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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