HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → 1-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | 2-Fluoro-5-(trifluoromethyl)benzonitrile | HCID 521016 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine | HCID 28875377 | — |
Reaction Steps
2-Fluoro-5-trifluoromethyl-benzonitrile (Matrix, 6.5 g, 34.4 mmol) and methylhydrazine (Aldrich, 2.72 mL, 51.6 mmol) in IPA (10 mL) were heated to reflux for 2 hours. The solvent was removed to afford the title compound as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436023B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c70b37dadfc24ca081789438a30a9572 |
| Source note | uspto-grants-2013_05 |