Methylhydrazine → 1-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine

HRID 2089148Notes

Reaction equation

HRID 2089148 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[C:4]#[N:5].[CH3:14][NH:15][NH2:16]>CC(O)C>[CH3:14][N:15]1[C:2]2[C:3](=[CH:6][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:8][CH:9]=2)[C:4]([NH2:5])=[N:16]1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 5210162-Fluoro-5-(trifluoromethyl)benzonitrile

Product 1

HCID 288753771-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-Fluoro-5-trifluoromethyl-benzonitrile (Matrix, 6.5 g, 34.4 mmol) and methylhydrazine (Aldrich, 2.72 mL, 51.6 mmol) in IPA (10 mL) were heated to reflux for 2 hours. The solvent was removed to afford the title compound as white solid.

Workup

  1. temperatureto reflux for 2 hours
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-c70b37dadfc24ca081789438a30a9572
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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