Trifluoroacetic acid → N-Azetidin-3-yl-2-(1-methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt

HRID 2089151Notes

Reaction equation

[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(OC([N:15]1[CH2:18][CH:17]([NH:19][C:20](=[O:37])[CH2:21][NH:22][C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[C:29]([C:32]([F:35])([F:34])[F:33])[CH:30]=3)[N:25]([CH3:36])[N:24]=2)[CH2:16]1)=O)(C)(C)C>>[OH:7][C:1]([C:3]([F:6])([F:5])[F:4])=[O:2].[NH:15]1[CH2:16][CH:17]([NH:19][C:20](=[O:37])[CH2:21][NH:22][C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[C:29]([C:32]([F:33])([F:35])[F:34])[CH:30]=3)[N:25]([CH3:36])[N:24]=2)[CH2:18]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 674791243-[2-(1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86660178N-Azetidin-3-yl-2-(1-methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt

Procedure

The title compound was prepared as colorless oil from TFA treatment of 3-[2-(1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester using the procedure described in Step D of Example 1.

Sources & evidence

ORD record: ord-a191f50d80fa4acfa555c6f0f86e18d7
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436023B2

Reaction notes

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