Ethanolamine → HCID 54754846, compound

HRID 2089178Notes

Reaction equation

HRID 2089178 reaction equation
CCN=C=NCCCN(C)C.[CH3:12][N:13]1[C:21]2[C:16](=[CH:17][C:18]([C:22]([F:25])([F:24])[F:23])=[CH:19][CH:20]=2)[C:15]([NH:26][CH2:27][C:28]([NH:30][CH:31]2[CH2:34][N:33]([CH:35]3[CH2:40][CH2:39][CH:38]([C:41]([OH:43])=O)[CH2:37][CH2:36]3)[CH2:32]2)=[O:29])=[N:14]1.[NH2:44][CH2:45][CH2:46][OH:47]>>[OH:47][CH2:46][CH2:45][NH:44][C:41]([CH:38]1[CH2:39][CH2:40][CH:35]([N:33]2[CH2:34][CH:31]([NH:30][C:28](=[O:29])[CH2:27][NH:26][C:15]3[C:16]4[C:21](=[CH:20][CH:19]=[C:18]([C:22]([F:23])([F:24])[F:25])[CH:17]=4)[N:13]([CH3:12])[N:14]=3)[CH2:32]2)[CH2:36][CH2:37]1)=[O:43]

Participants

4

Reactant 3

HCID 700EthanolamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 56661559HCID 56661559, compound

Product 1

HCID 54754846HCID 54754846, compound

Procedure

The title compound was prepared from EDCI coupling of 4-{3-[2-(1-methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexanecarboxylic acid (as prepared in Example 39, Step A) and 2-aminoethanol using the procedure described in Example 39.

Sources & evidence

ORD record
ord-981838e9aaec4b038f530c341421057b
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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