Iodoethane → N-[1-(4-Methoxymethyl-cyclohexyl)-azetidin-3-yl]-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide

HRID 2089187Notes

Reaction equation

HRID 2089187 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[NH:11][N:10]=2)[CH2:2]1.[CH3:23][O:24][CH2:25][CH:26]1[CH2:31][CH2:30][C:29](=O)[CH2:28][CH2:27]1.C(I)C>>[CH3:23][O:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH:29]([N:1]2[CH2:2][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:20])([F:19])[F:21])[CH:16]=4)[NH:11][N:10]=3)[CH2:4]2)[CH2:28][CH2:27]1

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 578290164-(Methoxymethyl)cyclohexan-1-oneHCID 58548846HCID 58548846, compound

Product 1

HCID 54755080N-[1-(4-Methoxymethyl-cyclohexyl)-azetidin-3-yl]-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide (as prepared in Example 41, Step A) and 4-methoxymethyl-cyclohexanone (following the procedure described in Example 34, substituting methyl iodide for ethyl iodide) using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-9799536d7c114f9bb2a4011958191065
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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