HRID2089195

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID59361558

未命名化合物

结构：Cn1nc(NCC(=O)NC2CNC2)c2cc(C(O)C(F)(F)F)ccc21.O=C(O)C(F)(F)F

HCID86660179

未命名化合物

PRODUCTS

生成物

结构：CCc1ncc(C2(O)CCC(N3CC(NC(=O)CNc4nn(C)c5ccc(C(O)C(F)(F)F)cc45)C3)CC2)s1

HCID54755314

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-[1-methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetamide TFA salt (as prepared in Example 60, Step B) and 4-(2-ethyl-thiazol-5-yl)-4-hydroxy-cyclohexanone using the procedure described in Step E of Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b085390531d64676b8b087dfe6a646d8
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436023B2
来源说明: uspto-grants-2013_05

反应 SMILES

OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:32])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([CH:25]([OH:30])[C:26]([F:29])([F:28])[F:27])[CH:23]=3)[N:18]([CH3:31])[N:17]=2)[CH2:9]1.[CH2:33]([C:35]1[S:36][C:37]([C:40]2([OH:47])[CH2:45][CH2:44][C:43](=O)[CH2:42][CH2:41]2)=[CH:38][N:39]=1)[CH3:34]>>[CH2:33]([C:35]1[S:36][C:37]([C:40]2([OH:47])[CH2:41][CH2:42][CH:43]([N:8]3[CH2:11][CH:10]([NH:12][C:13](=[O:32])[CH2:14][NH:15][C:16]4[C:24]5[C:19](=[CH:20][CH:21]=[C:22]([CH:25]([OH:30])[C:26]([F:29])([F:28])[F:27])[CH:23]=5)[N:18]([CH3:31])[N:17]=4)[CH2:9]3)[CH2:44][CH2:45]2)=[CH:38][N:39]=1)[CH3:34]