HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexanone → N-{1-[4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexyl]-azetidin-3-yl}-2-[1-methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexanone | HCID 59361558 | — |
| Reactant | N-azetidin-3-yl-2-[1-methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetamide TFA salt | HCID 86660179 | — |
| Product | N-{1-[4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexyl]-azetidin-3-yl}-2-[1-methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetamide | HCID 54755314 | — |
Reaction Steps
The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-[1-methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetamide TFA salt (as prepared in Example 60, Step B) and 4-(2-ethyl-thiazol-5-yl)-4-hydroxy-cyclohexanone using the procedure described in Step E of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436023B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-b085390531d64676b8b087dfe6a646d8 |
| Source note | uspto-grants-2013_05 |