HRID2089207

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID59361558

未命名化合物

结构：O=C(CNc1nn(CC(F)(F)F)c2ccc(C(F)(F)F)cc12)NC1CNC1.O=C(O)C(F)(F)F

HCID86660182

未命名化合物

PRODUCTS

生成物

结构：CCc1ncc(C2(O)CCC(N3CC(NC(=O)CNc4nn(CC(F)(F)F)c5ccc(C(F)(F)F)cc45)C3)CC2)s1

HCID54755677

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from reaction of N-(azetidin-3-yl)-2-((1-(2,2,2-trifluoroethyl)-5-(trifluoromethyl)-1H-indazol-3-yl)amino)acetamide TFA salt (as prepared in Example 72, Step A) and 4-(2-ethyl-thiazol-5-yl)-4-hydroxy-cyclohexanone using the procedure described in Step E of Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-53ccf7e5b0bc4a0cb5ef0f9685dd6f54
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436023B2
来源说明: uspto-grants-2013_05

反应 SMILES

OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:34])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([CH2:29][C:30]([F:33])([F:32])[F:31])[N:17]=2)[CH2:9]1.[CH2:35]([C:37]1[S:38][C:39]([C:42]2([OH:49])[CH2:47][CH2:46][C:45](=O)[CH2:44][CH2:43]2)=[CH:40][N:41]=1)[CH3:36]>>[CH2:35]([C:37]1[S:38][C:39]([C:42]2([OH:49])[CH2:43][CH2:44][CH:45]([N:8]3[CH2:11][CH:10]([NH:12][C:13](=[O:34])[CH2:14][NH:15][C:16]4[C:24]5[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:27])([F:28])[F:26])[CH:23]=5)[N:18]([CH2:29][C:30]([F:31])([F:32])[F:33])[N:17]=4)[CH2:9]3)[CH2:46][CH2:47]2)=[CH:40][N:41]=1)[CH3:36]