AGN-PC-0ND25R → N-[1-(4-Benzo[1,3]dioxol-5-yl-cyclohexyl)-azetidin-3-yl]-2-[1-(2-hydroxy-ethyl)-5-trifluoromethyl-1H-indazol-3-ylamino]-acetamide

HRID 2089211Notes

Reaction equation

HRID 2089211 reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:32])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([CH2:29][CH2:30][OH:31])[N:17]=2)[CH2:9]1.[O:33]1[C:37]2[CH:38]=[CH:39][C:40]([CH:42]3[CH2:47][CH2:46][C:45](=O)[CH2:44][CH2:43]3)=[CH:41][C:36]=2[O:35][CH2:34]1>>[O:33]1[C:37]2[CH:38]=[CH:39][C:40]([CH:42]3[CH2:47][CH2:46][CH:45]([N:8]4[CH2:11][CH:10]([NH:12][C:13](=[O:32])[CH2:14][NH:15][C:16]5[C:24]6[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=6)[N:18]([CH2:29][CH2:30][OH:31])[N:17]=5)[CH2:9]4)[CH2:44][CH2:43]3)=[CH:41][C:36]=2[O:35][CH2:34]1

Participants

3

Reactant 2

HCID 10932904AGN-PC-0ND25RHCID 86660184HCID 86660184, compound

Product 1

HCID 54755801N-[1-(4-Benzo[1,3]dioxol-5-yl-cyclohexyl)-azetidin-3-yl]-2-[1-(2-hydroxy-ethyl)-5-trifluoromethyl-1H-indazol-3-ylamino]-acetamide

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-[1-(2-hydroxy-ethyl)-5-trifluoromethyl-1H-indazol-3-ylamino]-acetamide TFA salt (as prepared in Example 74, Step A) and 4-benzo[1,3]dioxol-5-yl-cyclohexanone using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-e79a552cab2440c293a6a0604677fd8a
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

Loading…