Phthalic Anhydride → 2-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

HRID 2089213Notes

Reaction equation

HRID 2089213 reaction equation
[C:1]1(=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])O1.[F:12][C:13]([F:25])([F:24])[C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][N:18]=[C:17]2[NH2:23]>O1CCOCC1>[F:25][C:13]([F:12])([F:24])[C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][N:18]=[C:17]2[N:23]1[C:3](=[O:10])[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:1]1=[O:11]

Participants

4

Reactant 2

HCID 6811Phthalic AnhydrideHCID 16736Bay-H-1127

Product 1

HCID 585488622-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Isobenzofuran-1,3-dione (4.24 g, 28.6 mmol) and 5-trifluoromethyl-1H-indazol-3-ylamine (5.76 g, 28.6 mmol) in dioxane (10 mL) in a sealed tube were heated at 100° C. overnight. The solvent was removed to give the crude product.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-1754c6b4a921448496e0b5417213958d
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

Loading…