HRID2089219

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CCOc1ccc(C2(O)CCC(N3CC(NC(=O)CNc4nn(C(=O)NC(C)(C)C)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1

HCID54755800

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(C2(O)CCC(N3CC(NC(=O)CNc4nn(C(N)=O)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1

HCID54755802

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from de-protection of 3-[({1-[4-(6-ethoxy-pyridin-3-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butylamide (as prepared in Example 82) with TFA using the procedure described in Example 81.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8e80c7e5e85c4e9c9f700275803febaa
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436023B2
来源说明: uspto-grants-2013_05

反应 SMILES

C([NH:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:14][CH:15]=2)[C:10]([NH:21][CH2:22][C:23](=[O:45])[NH:24][CH:25]2[CH2:28][N:27]([CH:29]3[CH2:34][CH2:33][C:32]([C:36]4[CH:37]=[N:38][C:39]([O:42][CH2:43][CH3:44])=[CH:40][CH:41]=4)([OH:35])[CH2:31][CH2:30]3)[CH2:26]2)=[N:9]1)=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>>[CH2:43]([O:42][C:39]1[N:38]=[CH:37][C:36]([C:32]2([OH:35])[CH2:33][CH2:34][CH:29]([N:27]3[CH2:28][CH:25]([NH:24][C:23]([CH2:22][NH:21][C:10]4[C:11]5[C:16](=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=5)[N:8]([C:6]([NH2:5])=[O:7])[N:9]=4)=[O:45])[CH2:26]3)[CH2:30][CH2:31]2)=[CH:41][CH:40]=1)[CH3:44]