Trifluoroacetic acid → 3-[({1-[4-(6-Ethoxy-pyridin-3-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid amide
Reaction equation
C([NH:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:14][CH:15]=2)[C:10]([NH:21][CH2:22][C:23](=[O:45])[NH:24][CH:25]2[CH2:28][N:27]([CH:29]3[CH2:34][CH2:33][C:32]([C:36]4[CH:37]=[N:38][C:39]([O:42][CH2:43][CH3:44])=[CH:40][CH:41]=4)([OH:35])[CH2:31][CH2:30]3)[CH2:26]2)=[N:9]1)=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>>[CH2:43]([O:42][C:39]1[N:38]=[CH:37][C:36]([C:32]2([OH:35])[CH2:33][CH2:34][CH:29]([N:27]3[CH2:28][CH:25]([NH:24][C:23]([CH2:22][NH:21][C:10]4[C:11]5[C:16](=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=5)[N:8]([C:6]([NH2:5])=[O:7])[N:9]=4)=[O:45])[CH2:26]3)[CH2:30][CH2:31]2)=[CH:41][CH:40]=1)[CH3:44]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared as a white solid from de-protection of 3-[({1-[4-(6-ethoxy-pyridin-3-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butylamide (as prepared in Example 82) with TFA using the procedure described in Example 81.
Sources & evidence
- ORD record
- ord-8e80c7e5e85c4e9c9f700275803febaa
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08436023B2
Reaction notes
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