HRID2089220

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10609430

4-(tert-Butyldimethylsilyloxy)cyclohexanone

C12H24O2Si

结构：CC(C)(C)NC(=O)n1nc(NCC(=O)NC2CNC2)c2cc(C(F)(F)F)ccc21.O=C(O)C(F)(F)F

HCID131730555

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)NC(=O)n1nc(NCC(=O)NC2CN(C3CCC(O[Si](C)(C)C(C)(C)C)CC3)C2)c2cc(C(F)(F)F)ccc21

HCID67478955

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from reaction of 3-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butyl amide TFA salt (as prepared in Example 81, Step D) and 4-(tert-butyl-dimethyl-silanyloxy)-cyclohexanone using the procedure described in Step E of Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9d152fa4fe31448aa35082eba20e928d
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436023B2
来源说明: uspto-grants-2013_05

反应 SMILES

OC(C(F)(F)F)=O.[C:8]([NH:12][C:13]([N:15]1[C:23]2[C:18](=[CH:19][C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=2)[C:17]([NH:28][CH2:29][C:30](=[O:36])[NH:31][CH:32]2[CH2:35][NH:34][CH2:33]2)=[N:16]1)=[O:14])([CH3:11])([CH3:10])[CH3:9].[C:37]([Si:41]([CH3:51])([CH3:50])[O:42][CH:43]1[CH2:48][CH2:47][C:46](=O)[CH2:45][CH2:44]1)([CH3:40])([CH3:39])[CH3:38]>>[C:8]([NH:12][C:13]([N:15]1[C:23]2[C:18](=[CH:19][C:20]([C:24]([F:26])([F:25])[F:27])=[CH:21][CH:22]=2)[C:17]([NH:28][CH2:29][C:30](=[O:36])[NH:31][CH:32]2[CH2:33][N:34]([CH:46]3[CH2:47][CH2:48][CH:43]([O:42][Si:41]([C:37]([CH3:40])([CH3:39])[CH3:38])([CH3:50])[CH3:51])[CH2:44][CH2:45]3)[CH2:35]2)=[N:16]1)=[O:14])([CH3:11])([CH3:9])[CH3:10]