HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(tert-Butyldimethylsilyloxy)cyclohexanone → 3-[({1-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(tert-Butyldimethylsilyloxy)cyclohexanone | HCID 10609430 | — |
| Reactant | 3-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butyl amide TFA salt | HCID 131730555 | — |
| Product | 3-[({1-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butylamide | HCID 67478955 | — |
Reaction Steps
The title compound was prepared as a white solid from reaction of 3-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butyl amide TFA salt (as prepared in Example 81, Step D) and 4-(tert-butyl-dimethyl-silanyloxy)-cyclohexanone using the procedure described in Step E of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436023B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-9d152fa4fe31448aa35082eba20e928d |
| Source note | uspto-grants-2013_05 |