Trifluoroacetic acid → 4-{3-[2-(1-Carbamoyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexane carboxylic acid ethyl ester

HRID 2089225Notes

Reaction equation

[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH:9]([N:12]2[CH2:15][CH:14]([NH:16][C:17](=[O:40])[CH2:18][NH:19][C:20]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([C:29]([F:32])([F:31])[F:30])[CH:27]=4)[N:22]([C:33](=[O:39])[NH:34]C(C)(C)C)[N:21]=3)[CH2:13]2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].C(O)(C(F)(F)F)=O>>[CH2:1]([O:3][C:4]([CH:6]1[CH2:7][CH2:8][CH:9]([N:12]2[CH2:15][CH:14]([NH:16][C:17](=[O:40])[CH2:18][NH:19][C:20]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([C:29]([F:31])([F:32])[F:30])[CH:27]=4)[N:22]([C:33](=[O:39])[NH2:34])[N:21]=3)[CH2:13]2)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 54756043HCID 54756043, compound

Product 1

HCID 547560454-{3-[2-(1-Carbamoyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexane carboxylic acid ethyl ester

Procedure

The title compound was prepared as a white solid from de-protection of 4-{3-[2-(1-tert-butylcarbamoyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexanecarboxylic acid ethyl ester (as prepared in Example 88) with TFA using the procedure described in Example 81.

Sources & evidence

ORD record: ord-25517f6c61234ef0b5dd33c816efb8f7
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436023B2

Reaction notes

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