4-Isopropylcyclohexanone → 3-({[1-(4-Isopropyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-amino)-5-trifluoromethyl-indazole-1-carboxylic acid isopropylamide

HRID 2089228Notes

Reaction equation

HRID 2089228 reaction equation
[CH:1]([NH:4][C:5]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([C:16]([F:19])([F:18])[F:17])=[CH:13][CH:14]=2)[C:9]([NH:20][CH2:21][C:22](=[O:28])[NH:23][CH:24]2[CH2:27][NH:26][CH2:25]2)=[N:8]1)=[O:6])([CH3:3])[CH3:2].[CH:29]([CH:32]1[CH2:37][CH2:36][C:35](=O)[CH2:34][CH2:33]1)([CH3:31])[CH3:30]>>[CH:1]([NH:4][C:5]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([C:16]([F:18])([F:19])[F:17])=[CH:13][CH:14]=2)[C:9]([NH:20][CH2:21][C:22](=[O:28])[NH:23][CH:24]2[CH2:25][N:26]([CH:35]3[CH2:36][CH2:37][CH:32]([CH:29]([CH3:31])[CH3:30])[CH2:33][CH2:34]3)[CH2:27]2)=[N:8]1)=[O:6])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 794884-IsopropylcyclohexanoneHCID 585488583-[(Azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid isopropylamide

Product 1

HCID 547560423-({[1-(4-Isopropyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-amino)-5-trifluoromethyl-indazole-1-carboxylic acid isopropylamide

Procedure

The title compound was prepared as a white solid from reaction of 3-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid isopropylamide (as prepared in Example 90, Step A) and 4-iso-propyl-cyclohexanone using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-9bb86a2fd87a42eaadbb207918a0c0ff
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

Loading…