(1,1'-Bicyclohexyl)-4-one → 3-{[(1-Bicyclohexyl-4-yl-azetidin-3-ylcarbamoyl)-methyl]-amino}-5-trifluoromethyl-indazole-1-carboxylic acid isopropylamide

HRID 2089229Notes

Reaction equation

HRID 2089229 reaction equation
[CH:1]([NH:4][C:5]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([C:16]([F:19])([F:18])[F:17])=[CH:13][CH:14]=2)[C:9]([NH:20][CH2:21][C:22](=[O:28])[NH:23][CH:24]2[CH2:27][NH:26][CH2:25]2)=[N:8]1)=[O:6])([CH3:3])[CH3:2].[CH:29]1([CH:36]2[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]2)[CH2:34][CH2:33][C:32](=O)[CH2:31][CH2:30]1>>[CH:1]([NH:4][C:5]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([C:16]([F:18])([F:19])[F:17])=[CH:13][CH:14]=2)[C:9]([NH:20][CH2:21][C:22](=[O:28])[NH:23][CH:24]2[CH2:25][N:26]([CH:39]3[CH2:40][CH2:41][CH:36]([CH:29]4[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]4)[CH2:37][CH2:38]3)[CH2:27]2)=[N:8]1)=[O:6])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 41690(1,1'-Bicyclohexyl)-4-oneHCID 585488583-[(Azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid isopropylamide

Product 1

HCID 547560443-{[(1-Bicyclohexyl-4-yl-azetidin-3-ylcarbamoyl)-methyl]-amino}-5-trifluoromethyl-indazole-1-carboxylic acid isopropylamide

Procedure

The title compound was prepared as a white solid from reaction of 3-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid isopropylamide (as prepared in Example 90, Step A) and bicyclohexyl-4-one using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-7894da8f7f864c50949cb2d17473e844
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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