HRID2089237

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67478868

未命名化合物

结构：CS(=O)(=O)n1nc(NCC(=O)NC2CNC2)c2cc(C(F)(F)F)ccc21.O=C(O)C(F)(F)F

HCID86660185

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2CCC(N3CC(NC(=O)CNc4nn(S(C)(=O)=O)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1

HCID67478769

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(1-methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt and 4-(6-methoxy-pyridin-3-yl)-cyclohexanone using the procedure described in Step E of Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1a5a82a7f4d742aaa050c7e9fa32ba54
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436023B2
来源说明: uspto-grants-2013_05

反应 SMILES

OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:33])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([S:29]([CH3:32])(=[O:31])=[O:30])[N:17]=2)[CH2:9]1.[CH3:34][O:35][C:36]1[N:41]=[CH:40][C:39]([CH:42]2[CH2:47][CH2:46][C:45](=O)[CH2:44][CH2:43]2)=[CH:38][CH:37]=1>>[CH3:32][S:29]([N:18]1[C:19]2[C:24](=[CH:23][C:22]([C:25]([F:27])([F:28])[F:26])=[CH:21][CH:20]=2)[C:16]([NH:15][CH2:14][C:13]([NH:12][CH:10]2[CH2:11][N:8]([CH:45]3[CH2:46][CH2:47][CH:42]([C:39]4[CH:40]=[N:41][C:36]([O:35][CH3:34])=[CH:37][CH:38]=4)[CH2:43][CH2:44]3)[CH2:9]2)=[O:33])=[N:17]1)(=[O:31])=[O:30]