4-(6-Methoxypyridin-3-yl)cyclohexanone → 2-(1-Methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-N-{1-[4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-acetamide

HRID 2089237Notes

Reaction equation

HRID 2089237 reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:33])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([S:29]([CH3:32])(=[O:31])=[O:30])[N:17]=2)[CH2:9]1.[CH3:34][O:35][C:36]1[N:41]=[CH:40][C:39]([CH:42]2[CH2:47][CH2:46][C:45](=O)[CH2:44][CH2:43]2)=[CH:38][CH:37]=1>>[CH3:32][S:29]([N:18]1[C:19]2[C:24](=[CH:23][C:22]([C:25]([F:27])([F:28])[F:26])=[CH:21][CH:20]=2)[C:16]([NH:15][CH2:14][C:13]([NH:12][CH:10]2[CH2:11][N:8]([CH:45]3[CH2:46][CH2:47][CH:42]([C:39]4[CH:40]=[N:41][C:36]([O:35][CH3:34])=[CH:37][CH:38]=4)[CH2:43][CH2:44]3)[CH2:9]2)=[O:33])=[N:17]1)(=[O:31])=[O:30]

Participants

3

Reactant 2

HCID 674788684-(6-Methoxypyridin-3-yl)cyclohexanoneHCID 86660185N-azetidin-3-yl-2-(1-methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt

Product 1

HCID 674787692-(1-Methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-N-{1-[4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-acetamide

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(1-methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt and 4-(6-methoxy-pyridin-3-yl)-cyclohexanone using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-1a5a82a7f4d742aaa050c7e9fa32ba54
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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