反应详情

A flask was charged with ca. 1 mmol of 4-Methylsulfanyl-2′-nitro-biphenyl-2-ylamine, 15 mL of ethanol, and 0.1 mmol of PtO2, and stirred under hydrogen atmosphere at 40 psi for 10 minutes. The reaction mixture was filtered through diatomaceous earth, washed with ethanol, and the combined organic layer was evaporated to dryness. The crude material was purified by preparative HPLC. The same material can also be prepared by the previous method, (Suzuki coupling conditions) starting from 4-iodo-3-aminothioanisole, and purified by preparative HPLC.

1. filtrationThe reaction mixture was filtered through diatomaceous earth
2. washwashed with ethanol
3. customthe combined organic layer was evaporated to dryness
4. customThe crude material was purified by preparative HPLC
5. customThe same material can also be prepared by the previous method, (Suzuki coupling conditions)
6. custompurified by preparative HPLC