HCID 131730558, compound → HCID 131730557, compound

HRID 2089509Notes

Reaction equation

HRID 2089509 reaction equation
[C:1]([SiH2:5][O:6][C:7]([CH3:26])([CH3:25])[C:8]1[N:12]([CH:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]([OH:22])[C:14]2([CH3:24])[CH3:23])[CH:11]=[N:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>O1CCOCC1.[O-2].[Mn+4].[O-2]>[C:1]([SiH2:5][O:6][C:7]([CH3:26])([CH3:25])[C:8]1[N:12]([CH:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[O:22])[C:14]2([CH3:24])[CH3:23])[CH:11]=[N:10][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 131730558HCID 131730558, compound

Product 1

HCID 131730557HCID 131730557, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 3-[5-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-2,2-dimethyl-indan-1-ol (372 mg, 1.0 mmol) in 1,4-dioxane is added manganese(IV) oxide (1.74 g, 20 mmol). The reaction is then heated at 100° C. for one hour, cooled to room temperature, filtered, and concentrated to afford 3-[5-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-2,2-dimethyl-indan-1-one without the need for further purification; MS: (ESI) m/z 371.1 (M+H)+.

Workup

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-dbddc0fc21364287b5eaa2b345a0fb70
Source dataset
uspto-grants-2013_05
Patent number
US08436035B2

Reaction notes

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