HCID 131730558, compound → HCID 131730557, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-[5-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-2,2-dimethyl-indan-1-ol (372 mg, 1.0 mmol) in 1,4-dioxane is added manganese(IV) oxide (1.74 g, 20 mmol). The reaction is then heated at 100° C. for one hour, cooled to room temperature, filtered, and concentrated to afford 3-[5-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-2,2-dimethyl-indan-1-one without the need for further purification; MS: (ESI) m/z 371.1 (M+H)+.

Provenance & Evidence