HCID 59199399, compound → HCID 59199428, compound

HRID 2089515Notes

Reaction equation

HRID 2089515 reaction equation
[CH3:1][C:2]1([CH3:18])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[N:11]1[C:15]([CH2:16][OH:17])=[CH:14][N:13]=[CH:12]1>O1CCOCC1.[O-2].[Mn+4].[O-2]>[CH3:1][C:2]1([CH3:18])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[N:11]1[C:15]([CH:16]=[O:17])=[CH:14][N:13]=[CH:12]1

Participants

4

Reactant 1

HCID 59199399HCID 59199399, compound

Product 1

HCID 59199428HCID 59199428, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of [3-(2,2-dimethyl-indan-1-yl)-3H-imidazol-4-yl]-methanol (120 mg, 0.5 mmol), which can be prepared as described in Example 23, in 1,4-dioxane (5 mL) is added manganese (IV) oxide (434 mg, 5 mmol). The reaction is then heated at 90° C. for 1 hour, at which time the reaction is cooled to room temperature and filtered to furnish 3-(2,2-dimethyl-indan-1-yl)-3H-imidazole-4-carbaldehyde without the need for further purification; MS: (ESI) m/z 241.1 (M+H)+.

Workup

  1. temperatureis cooled to room temperature
  2. filtrationfiltered

Sources & evidence

ORD record
ord-2a9a18be03bf48f6bdba28006049a85f
Source dataset
uspto-grants-2013_05
Patent number
US08436035B2

Reaction notes

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