Tetrahydro-4H-pyran-4-one → HCID 25213245, compound

HRID 2089577Notes

Reaction equation

HRID 2089577 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH3:17])[CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=[CH:7]2.O=[C:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[O:22]1[CH2:23][CH2:24][CH:19]([NH:1][C:2]2[CH:3]=[C:4]([CH3:17])[CH:5]=[C:6]3[C:10]=2[NH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:7]3)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 68474590HCID 68474590, compound

Product 1

HCID 25213245HCID 25213245, compoundYield 36%

Procedure

7-Amino-5-methyl-2-(pyridin-2-yl)-1H-indole prepared in Step A of Example 1 and 4-oxo-tetrahydropyran were reacted according to the same procedure as Step B of Example 1 to give the title compound (25 mg, Yield 36%).

Sources & evidence

ORD record
ord-32a0237ebb274d658d7d0f81a02aeb31
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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