Tetrahydro-4H-pyran-4-one → Necrox-7

HRID 2089593Notes

Reaction equation

HRID 2089593 reaction equation
[O:1]=[S:2]1(=[O:27])[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]3[C:15](=[C:16]([N+:18]([O-])=O)[CH:17]=2)[NH:14][C:13]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:12]3)[CH2:4][CH2:3]1.[O:28]1[CH2:33][CH2:32][C:31](=O)[CH2:30][CH2:29]1>>[O:28]1[CH2:33][CH2:32][CH:31]([NH:18][C:16]2[CH:17]=[C:9]([CH2:8][N:5]3[CH2:6][CH2:7][S:2](=[O:27])(=[O:1])[CH2:3][CH2:4]3)[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:12]3)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 684718685-(1,1-Dioxo-thiomorpholin-4-yl)methyl-2-phenyl-7-nitro-1H-indole

Product 1

HCID 44187164Necrox-7

Procedure

5-(1,1-Dioxo-thiomorpholin-4-yl)methyl-2-phenyl-7-nitro-1H-indole prepared in Step B and tetrahydropyran-4-one were reacted according to the same procedure as Example 1 to give the title compound.

Sources & evidence

ORD record
ord-513745de13a94ff2adcb3d49adbd92e7
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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