Trifluoroacetic acid → HCID 25215914, compound

HRID 2089597Notes

Reaction equation

HRID 2089597 reaction equation
[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([Cl:30])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13](C2C=CC(C(OC(C)(C)C)=O)=CC=2N)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:31](O)([C:33](F)(F)F)=O>C(Cl)Cl>[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([Cl:30])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:33]2[CH:31]=[CH:5][C:1]([NH2:6])=[CH:2][CH:3]=2)=[CH:12]3)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 68473900HCID 68473900, compound

Product 1

HCID 25215914HCID 25215914, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Cyclopentyl-[2-(4-BOC-aminophenyl)-5-chloro-1H-indol-7-yl]-amine (430 mg, 1 mmol) prepared in Example 78 was added to DCM (5 mL). TFA (5 mL) was added thereto, and the mixture was stirred for 2 h. After completion of the reaction, TFA was removed under reduced pressure, and the residue was purified by column chromatography to give the title compound (310 mg, Yield 95%).

Workup

  1. customwas removed under reduced pressure
  2. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-f0db329ad58941658a0e90ce5cf6e34d
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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