N-(tert-butoxycarbonyl)glycine → HCID 68471572, compound

HRID 2089605Notes

Reaction equation

HRID 2089605 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:5]2.[NH:24](C(OC(C)(C)C)=O)[CH2:25][C:26](O)=[O:27]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:13][CH2:14][N:15]([C:26](=[O:27])[CH2:25][NH2:24])[CH2:16][CH2:17]3)[CH:10]=1)[NH:7][C:6]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 25216420HCID 25216420, compound

Product 1

HCID 68471572HCID 68471572, compound

Procedure

(5-Chloro-2-phenyl-1H-indol-7-yl)-piperidin-4-yl-amine prepared in Example 93 and N-BOC-Gly-OH were reacted according to the same procedure as Example 92 to give the title compound.

Sources & evidence

ORD record
ord-231fdffdef96486ab2fa3fab7e1471cb
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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