Pyrrolidine → Cyclopentyl-[2-phenyl-5-(2-pyrrolidin-1-yl-ethyl)-1H-indol-7-yl]-amine

HRID 2089615Notes

Reaction equation

HRID 2089615 reaction equation
[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([CH2:22][CH2:23]O)[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([CH2:22][CH2:23][N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 252141822-[7-(cyclopentylamino)-2-phenyl-1H-indol-5-yl]ethanol

Product 1

HCID 68480406Cyclopentyl-[2-phenyl-5-(2-pyrrolidin-1-yl-ethyl)-1H-indol-7-yl]-amine

Procedure

2-[7-Cyclopentylamino-2-phenyl-1H-indol-5-yl]-ethanol prepared in Example 32 and pyrrolidine were reacted according to the same procedures as Steps A and B of Example 36 to give the title compound.

Sources & evidence

ORD record
ord-15007d382b154cc9b654bd2791326d27
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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