反应详情

To a mixture of 3-methoxymethoxy-2,2-dimethylpropionic acid methoxymethyl ester (16.5 g) and methanol (30 mL), 5 N aqueous sodium hydroxide solution (30 mL) was added, and the resulting mixture was stirred at room temperature for 4 days. Ice was added to the mixture, and at 0° C., 5 N hydrochloric acid (35 mL) and diethyl ether (300 mL) were added thereto. The mixture was shaken and the organic layer was collected. The organic layer was washed with saturated aqueous sodium chloride solution (100 mL) and dried over anhydrous magnesium sulfate. The resulting mixture was filtered and the obtained filtrate was concentrated under reduced pressure to obtain the captioned compound (14.5 g).

1. additionwas added
2. additionIce was added to the mixture
3. stirringThe mixture was shaken
4. customthe organic layer was collected
5. washThe organic layer was washed with saturated aqueous sodium chloride solution (100 mL)
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationThe resulting mixture was filtered
8. concentrationthe obtained filtrate was concentrated under reduced pressure