Sodium Hydroxide → 4-({[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzonitrile

HRID 2089684Notes

Reaction equation

HRID 2089684 reaction equation
COC(=O)[O:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([CH:16]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]#[N:37])=[CH:32][CH:31]=2)[C:17]2[NH:21][C:20](=[O:22])[N:19]([C:23]3[N:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[N:18]=2)[C:9]=1[F:38].[OH-].[Na+]>O.C(O)(=O)C.O1CCCC1.CO>[F:38][C:9]1[C:8]([O:7][CH2:6][CH2:5][OH:4])=[CH:13][C:12]([O:14][CH3:15])=[CH:11][C:10]=1[CH:16]([NH:29][C:30]1[CH:31]=[CH:32][C:33]([C:36]#[N:37])=[CH:34][CH:35]=1)[C:17]1[NH:21][C:20](=[O:22])[N:19]([C:23]2[N:24]=[CH:25][CH:26]=[CH:27][N:28]=2)[N:18]=1

Participants

7

Reactant 2

HCID 14798Sodium HydroxideHCID 136334032Carbonic acid 2-{3-[(4-cyanophenylamino)-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]-triazol-3-yl)methyl]-2-fluoro-5-methoxyphenoxy}ethyl ester methyl ester

Product 1

HCID 1359820764-({[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzonitrileYield 87.5%

Reagents, catalysts & solvents 4

HCID 176Acetic AcidSolventHCID 887MethanolSolvent2×HCID 962WaterSolvent3×HCID 8028TetrahydrofuranSolvent2×

Procedure

To a mixture of the crude product of carbonic acid 2-{3-[(4-cyanophenylamino)-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]-triazol-3-yl)methyl]-2-fluoro-5-methoxyphenoxy}ethyl ester methyl ester (2.02 g), methanol (6 mL), tetrahydrofuran (6 mL), and water (2.3 mL), 5 N aqueous sodium hydroxide solution (3.71 mL, 18.6 mmol) was added. Methanol (2 mL), tetrahydrofuran (2 mL), and water (2 mL) were added to the reaction solution, and the resulting mixture was stirred at room temperature for 23 hours and 30 minutes. Acetic acid (4.25 mL) was added to the reaction solution, and the resulting mixture was stirred for 20 minutes, after which water (20 mL) was added dropwise thereto, and the resulting mixture was stirred at room temperature for 1 day. The precipitated solid was filtered and washed with water (6 mL) and tert-butyl methyl ether (6 mL). The solid obtained was dried under air flow to obtain the captioned compound (1.576 g) as a white solid.

Workup

  1. additionwas added
  2. stirringthe resulting mixture was stirred for 20 minutes
  3. stirringthe resulting mixture was stirred at room temperature for 1 day
  4. filtrationThe precipitated solid was filtered
  5. washwashed with water (6 mL) and tert-butyl methyl ether (6 mL)
  6. customThe solid obtained
  7. customwas dried under air flow

Sources & evidence

ORD record
ord-46a85733b17d4420a3d1c5191a40c80d
Source dataset
uspto-grants-2013_05
Patent number
US08436009B2

Reaction notes

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